College Football Week 10 Schedule and Betting Lines

CBS Sports Network will air six college football games during Week 10 of the 2026 season, beginning on Wednesday night. The schedule features a mix of Mid-Major conference contests and a rare appearance by a top-25 team in the Mountain West.

Toledo hosts Sacramento State at 7 p.m. ET on Wednesday at Hornet Stadium in Sacramento, California. The Rockets are heavy favorites, with a point spread of minus 25.5 against the Hornets. Sacramento State secured its first win over an FBS opponent and its first conference victory last week. Toledo quarterback John Alan Richter leads the Mid-American Conference with 173 completions, 2,244 passing yards, and 17 touchdowns. Defensive end Andrew Zock has recorded eight sacks and 12 tackles for loss for the Rockets.

No. 22 New Mexico travels to Reno, Nevada, to play the Wolf Pack on Friday at 9 p.m. ET. This marks the first time the Lobos have held a spot in the AP poll in the program’s 90-year history. New Mexico fields the nation’s best defense, allowing only 11.9 points per game. Nevada’s offense ranks 102nd in scoring, averaging 23.0 points per game. Running backs Scottre Humphrey and Kiefer Sibley have combined for more than 1,000 rushing yards this season. Humphrey leads the Mountain West with 11 touchdowns. The Lobos are a 9.5-point underdog in this matchup.

Saturday’s schedule kicks off at 12 p.m. ET with North Carolina visiting UConn at Rentschler Field in East Hartford, Connecticut. The Tar Heels are a 7-point favorite after falling just short of an upset over No. 1 Miami in the previous week. Quarterback Billy Edwards Jr. posted his best statistical performance of the season in that game. Navy hosts Temple at 3:30 p.m. ET in Annapolis, Maryland. Both teams hold a 2-6 record and have lost four one-point games this season. Navy is a 7.5-point favorite against the Owls.

The late Saturday slate includes Sam Houston visiting Jacksonville State at 7 p.m. ET in Jacksonville, Alabama. The Bearkats recently dismissed head coach Phil Longo. Jacksonville State is 4-0 in Conference USA play and seeks a third consecutive conference title game. Quarterback Caden Creel has thrown for 1,741 yards and 13 touchdowns while rushing for 713 yards and five scores. The Gamecocks are a 17.5-point favorite.

UNLV hosts Wyoming at 10:30 p.m. ET at Allegiant Stadium in Las Vegas, Nevada. Both Mountain West teams are 5-3. The Cowboys have won three straight games, including a recent victory over Air Force. The Rebels defeated Cal and North Dakota State but lost to Air Force before a bye week. UNLV is a 6-point favorite in the contest.